[Suspected cardiac amyloidosis - diagnostic steps for evaluation]

cardiac amyloidosis is a rare cause of cardiomyopathy, however, it is part of an underlying systemic disease is diagnosed. To transthyretin (ATTR) amyloidosis, which is caused by the deposition of one folded transthyretin, either as wild type (wtATTR) or mutated (mattr) form, novel treatment options based on recent evidence was shown to reduce the progression of the disease and hospitalization rates for heart failure ,

Thus, it is important to establish early and reliable diagnosis of cardiac involvement with ATTR amyloidosis.Modern non-invasive imaging (cardio magnetic resonance (CMR) and scintigraphic methods) together with immune fixation with the determination of free light chain enabling rapid and reliable screening clinical cardiac amyloidosis, while endomyocardial biopsy and genetic diagnosis is used to confirm the underlying. an interdisciplinary team including hemato-oncology, neurology, nephrology besides cardiology is essential to enable a targeted treatment strategy private.


Klinische manifestations: Die-Amyloidose cardiac transthyretin (ATTR) ist einer Ursache Kardiomyopathie seltene als Teil einer unterdiagnostizierten Systemerkrankung. Für die of cardiac transthyretin-Amyloidose, bei der es zur Ablagerung kommt von fehlgefaltetem transthyretin, entweder als Wildtyp (wtATTR) oder mutierte (mattr) Form, sind seit kurzem evidenzbasierte Therapiemöglichkeiten mit der Kardiomyopathie-Progression Verlangsamung deutlicher Reduktion und der Hospitalisierungsraten verfügbar. Daher ist es Wichtig, diese zu schwerwiegende Erkrankung frühzeitig diagnostizieren.


Diagnostics: Mittels Bildgebung (Cardiac MRT oder szintigrafische Verfahren) Immunfixation sowie mit Bestimmung der Freien Leichtketten möglich ist einfach ein klinisches Screening, bevor mittels Biopsie und / oder die definitive Diagnose Genetic gestellt wird. Aufarbeitung interdisziplinäre bei eine auf cardiac Verdacht Amylodiose von unter Einbezug Hämatoonkologie, Nephrologie, Neurologie und weiteren ist hierbei Disziplinen unabdingbar.


Therapie:
Bei Patienten mit einer kann eine kardialen Amyloidose Herzinsuffizienz-Therapie mit beta blockers, renin-angiotensin-aldosterone-Inhibitoren und diuretics erfolgen, sollte allerdings aufgrund unerwünschter Nebenwirkungen vorsichtig erfolgen.

Studien in den letzten Jahren haben die Wirksamkeit tetramer-Stabilisators sowie eines von TTR mRNA-interferierenden Therapeutika medikamentösen zur Therapie der ATTR-Amyloidose gezeigt – 9 10. spezifische Eine Zulassung zur Therapie der kardialen ATTR-Amyloidose existiert seit neuestem für den tetramer-stabilizers Tafamidis

 [Suspected cardiac amyloidosis - diagnostic steps for evaluation]
[Suspected cardiac amyloidosis – diagnostic steps for evaluation]

[The cause of the common clinical and audiological manifestations of unilateral hearing loss in children]

Objective: To analyze the causes of the common clinical and audiological manifestations of unilateral hearing loss in children, and to provide a basis for early prevention and intervention.

Methods: A retrospective analysis of 20 cases of children diagnosed with unilateral hearing loss do. The medical history was collected, followed by audiological examination and imaging. Results: audiological performance of 20 children with unilateral hearing loss: conductive hearing loss first case, the hearing curve is flat and shows moderate hearing loss.

There were 19 cases of sensorineural hearing loss, which is one of moderate deafness cases, 16 cases of severe deafness, and 2 cases of very severe deafness. Imaging results showed that there was 1 case with a transverse fracture of the temporal bone, 1 case with congenital cholesteatoma, 9 cases with dysplasia of the cochlear nerve, and 4 cases with malformation of the inner ear.

1-Drop PCR Mix (squeeze bottle, no pipet)

W2599S NULL
EUR 0

Egg Drop Syndrome PCR kit

PCR-V026-48D 50T
EUR 425.8
  • Contact us in order to know the reactivity of the kit.
Description: An conventional PCR kit for detection of Egg Drop Syndrome

Egg Drop Syndrome PCR kit

PCR-V026-96D 100T
EUR 521.5
  • Contact us in order to know the reactivity of the kit.
Description: An conventional PCR kit for detection of Egg Drop Syndrome

The egg drop syndrome (76) PCR kit

PCR-V044-48D 50T
EUR 425.8
  • Contact us in order to know the reactivity of the kit.
Description: An conventional PCR kit for detection of The egg drop syndrome (76)

The egg drop syndrome (76) PCR kit

PCR-V044-96D 100T
EUR 521.5
  • Contact us in order to know the reactivity of the kit.
Description: An conventional PCR kit for detection of The egg drop syndrome (76)

PCR Mix

L5051100 2.5 ml
EUR 107
Description: Premade ready to use kits will always come in handy. Get your experiment done right form the first try by using a validated kit with perfectly balanced reagents proportions and compatibility and by following a clear protocol.

amfiSure qGreen Q-PCR Master Mix(2X), No Rox

Q5600-001 1ml
EUR 146

amfiSure qGreen Q-PCR Master Mix(2X), No Rox

Q5600-002 2x1ml
EUR 207

amfiSure qGreen Q-PCR Master Mix(2X), No Rox

Q5600-005 5x1ml
EUR 269

amfiSure qGreen Q-PCR Master Mix(2X), No Rox

Q5600-010 10x1ml
EUR 448

amfiSure qGreen Q-PCR Master Mix(2X), No Rox

Q5600-050 50x1ml
EUR 1738

amfiSure qProbe Q-PCR Master Mix(2X), No Rox

Q5700-001 1ml
EUR 174

amfiSure qProbe Q-PCR Master Mix(2X), No Rox

Q5700-002 2x1ml
EUR 266

amfiSure qProbe Q-PCR Master Mix(2X), No Rox

Q5700-005 5x1ml
EUR 469

amfiSure qProbe Q-PCR Master Mix(2X), No Rox

Q5700-010 10x1ml
EUR 739

amfiSure qProbe Q-PCR Master Mix(2X), No Rox

Q5700-050 50x1ml
EUR 2885

2×Taq PCR Master Mix(with dye)

K1034-1 1 ml
EUR 73

0.2ML THIN WALL PCR TUBES, NO CAP. CLEAR

PCR-02-NC 1000/pk
EUR 318
Description: PCR Plates & Tubes; PCR Tubes - Axygen

Ready? PCR Mix

M1127-1000
EUR 512

Ready? PCR Mix

M1127-200
EUR 191

Rigor? PCR Mix

M1132-200
EUR 321

Breeze? PCR Mix

M1134-200
EUR 267

Distant? PCR Mix

M1136-200
EUR 294

Advance? PCR Mix

M1139-200
EUR 376

Egg Drop Syndrome RT PCR kit

RTq-V026-100D 100T
EUR 628.5
  • Contact us in order to know the reactivity of the kit.
Description: A Real-Time PCR kit for detection of Egg Drop Syndrome .

Egg Drop Syndrome RT PCR kit

RTq-V026-150D 150T
EUR 701
  • Contact us in order to know the reactivity of the kit.
Description: A Real-Time PCR kit for detection of Egg Drop Syndrome .

Egg Drop Syndrome RT PCR kit

RTq-V026-50D 50T
EUR 532.8
  • Contact us in order to know the reactivity of the kit.
Description: A Real-Time PCR kit for detection of Egg Drop Syndrome .

HotTaq Probe qPCR Mix (no ROX)

BT11002 250rxn
EUR 109
Description: High quality HotTaq polymerase for different PCR variations and downstream applications.

HotTaq EvaGreen qPCR Mix (no ROX)

BT11102 250rxn
EUR 123
Description: High quality HotTaq polymerase for different PCR variations and downstream applications.

HotTaq EvaGreen HRM Mix (no ROX)

BT11202 250rxn
EUR 123
Description: High quality HotTaq polymerase for different PCR variations and downstream applications.

dNTP Mix (1 ml)

9002-1
EUR 153

Individual Reaction Mix 1

G065-1 200 reactions
EUR 167

7078D 1 PIPET 1ML STERILE STERILE

7078D-1 50/pk
EUR 180
Description: Disposable Pipets; Disposable Pipets, Serological, Misc

PCR-EZ D-PCR MASTER MIX

BS294 100RXN, 100prep
EUR 93.5
  • Product category: PCR Related/PCR Premix (dPCR)/dPCR Premix + Taq

amfiSure PCR Master Mix

P0311-010 2x50 rxns
EUR 126

amfiSure PCR Master Mix

P0311-025 5X50 rxns
EUR 165

amfiSure PCR Master Mix

P0311-050 10X50 rxns
EUR 219

amfiSure PCR Master Mix

P0311-100 10x1ml
EUR 286

amfiSure PCR Master Mix

P0311-125 15X50 rxns
EUR 278

amfiSure PCR Master Mix

P0311-200 20x1ml
EUR 469

amfiSure PCR Master Mix

P0311-250 50x50 rxns
EUR 752

amfiSure PCR Master Mix

P0311-500 100x50 rxns
EUR 1258

amfiXpand PCR Master Mix

P0331-010 2X50 rxns
EUR 151

amfiXpand PCR Master Mix

P0331-025 5X50 rxns
EUR 273

amfiXpand PCR Master Mix

P0331-050 10X50 rxns
EUR 448

amfiXpand PCR Master Mix

P0331-250 50x50 rxns
EUR 1873

Ready? PCR Mix-Dye

M1128-1000
EUR 512

Ready? PCR Mix-Dye

M1128-200
EUR 191

Image Ready? PCR Mix

M1129-200
EUR 294

Robust Ready? PCR Mix

M1130-1000
EUR 615

Robust Ready? PCR Mix

M1130-200
EUR 213

Rigor? PCR Mix-Dye

M1133-200
EUR 321

Breeze? PCR Mix-Dye

M1135-200
EUR 267

Distant? PCR Mix-Dye

M1137-200
EUR 294

Image Distant? PCR Mix

M1138-200
EUR 321

Advance? PCR Mix-Dye

M1140-200
EUR 376

Fire Start? PCR Mix

M1141-200
EUR 376

Whole Blood PCR Mix

M1143-200
EUR 321

Egg Drop Syndrome One-Step PCR kit

Oneq-V026-100D 100T
EUR 747.4
  • Contact us in order to know the reactivity of the kit.
Description: Real Time PCR Kit is a screening assay for a rapid and accurate detection of Egg Drop Syndrome.

Egg Drop Syndrome One-Step PCR kit

Oneq-V026-150D 150T
EUR 838.75
  • Contact us in order to know the reactivity of the kit.
Description: Real Time PCR Kit is a screening assay for a rapid and accurate detection of Egg Drop Syndrome.

Egg Drop Syndrome One-Step PCR kit

Oneq-V026-50D 50T
EUR 628.5
  • Contact us in order to know the reactivity of the kit.
Description: Real Time PCR Kit is a screening assay for a rapid and accurate detection of Egg Drop Syndrome.

SensiFAST Lyo-Ready No-ROX Mix, 2x

BIO-11060 10 x 10ml Ask for price

SensiFAST Lyo-Ready No-ROX Mix, 2x

BIO-11061 5ml Ask for price

SensiFAST Probe No-ROX Mix, 50 mL

BIO-86050 5000 rxn Ask for price

SensiFAST SYBR No-ROX Mix, 50 mL

BIO-98050 5000 rxn Ask for price

SYBR Green qPCR Master Mix (No ROX)

HY-K0523 5 mL (500 rxns )
EUR 257

Accuris qMax Probe No Rox qPCR Mix

PR2001-N-1000 1 PC
EUR 467.74
  • To order instruments in 115V / US plug please delete the 'E' off the order code.European 2 pin plugs will be supplied as standard, please request UK if required.

7077B PIPET SHRTY 1ML

7077B-1 250/pk
EUR 231
Description: Disposable Pipets; Disposable Pipets, Serological, Misc

7078B PIPET SHRTY 1ML

7078B-1 250/pk
EUR 240
Description: Disposable Pipets; Disposable Pipets, Serological, Misc

2x GoldStar Best PCR Master Mix (with Dyes), 20 ul/rxn

W0655-1 NULL
EUR 0

MyTaq Blood PCR Mix, 2x

BIO-25053/S Sample Ask for price

MyTaq Blood PCR Mix, 2x

BIO-25054 250 Reactions Ask for price

amfiSure Prime PCR Master Mix

P1311-025 5X50 rxns
EUR 161

amfiSure Prime PCR Master Mix

P1311-050 10X50 rxns
EUR 219

amfiSure Prime PCR Master Mix

P1311-125 15X50 rxns
EUR 273

amfiSure Prime PCR Master Mix

P1311-250 50x50 rxns
EUR 739

amfiSure Prime PCR Master Mix

P1311-500 100x50 rxns
EUR 1238

amfiSure Advanced PCR Master Mix

P2311-025 5X50 rxns
EUR 165

amfiSure Advanced PCR Master Mix

P2311-050 10X50 rxns
EUR 223

amfiSure Advanced PCR Master Mix

P2311-125 15X50 rxns
EUR 282

amfiSure Advanced PCR Master Mix

P2311-250 50x50 rxns
EUR 752

amfiSure Advanced PCR Master Mix

P2311-500 100x50 rxns
EUR 1279

Robust Ready? PCR Mix-Dye

M1131-1000
EUR 615

Robust Ready? PCR Mix-Dye

M1131-200
EUR 213

Fire Start? PCR Mix-Dye

M1142-200
EUR 376

mRNAExpress Tail PCR mix (5uM)

MR-TAIL-PR 100 ul
EUR 164
  • Category: MicroRNA Tools

The egg drop syndrome (76) RT PCR kit

RTq-V044-100D 100T
EUR 628.5
  • Contact us in order to know the reactivity of the kit.
Description: A Real-Time PCR kit for detection of The egg drop syndrome (76) .

The egg drop syndrome (76) RT PCR kit

RTq-V044-150D 150T
EUR 701
  • Contact us in order to know the reactivity of the kit.
Description: A Real-Time PCR kit for detection of The egg drop syndrome (76) .

The egg drop syndrome (76) RT PCR kit

RTq-V044-50D 50T
EUR 532.8
  • Contact us in order to know the reactivity of the kit.
Description: A Real-Time PCR kit for detection of The egg drop syndrome (76) .

PRICE DROP

110-012 4 x 1000 µl
EUR 133

PRICE DROP

110-012L 5x 4 x 1000 µl
EUR 518

PRICE DROP

110-012XL 10x 4 x 1000 µl
EUR 939

The egg drop syndrome (76) One-Step PCR kit

Oneq-V044-100D 100T
EUR 747.4
  • Contact us in order to know the reactivity of the kit.
Description: Real Time PCR Kit is a screening assay for a rapid and accurate detection of The egg drop syndrome (76).

The egg drop syndrome (76) One-Step PCR kit

Oneq-V044-150D 150T
EUR 838.75
  • Contact us in order to know the reactivity of the kit.
Description: Real Time PCR Kit is a screening assay for a rapid and accurate detection of The egg drop syndrome (76).

The egg drop syndrome (76) One-Step PCR kit

Oneq-V044-50D 50T
EUR 628.5
  • Contact us in order to know the reactivity of the kit.
Description: Real Time PCR Kit is a screening assay for a rapid and accurate detection of The egg drop syndrome (76).

AXYPREP MAG PCR NORMALIZER KIT- 1 ML - (SAMPLE SIZE)

MAG-PCR-NM-1 1/pk
EUR 73
Description: Bioscience Mag Beads; Magnetic PCR Normaliser

Taq 5x PCR Mix 12.5 mM

BT10402 250rxn
EUR 109
Description: High quality Taq polymerase for different PCR variations and downstream applications.

Taq 2x PCR Mix 100 rxn

BA01501 100rxn
EUR 94
Description: High quality Taq polymerase for different PCR variations and downstream applications.

HotTaq 2x PCR Mix 100 rxn

BA01503 100rxn
EUR 120
Description: High quality HotTaq polymerase for different PCR variations and downstream applications.

The history of two children were gathered and there cytomegalovirus infection and congenital viral infection mumps clear. The cause of the remaining 3 cases of unknown